Lipedema Foundation Grants History

Lipedema Foundation was started in 2015 and its initial funding had 3 arms:

  • a very broad multi-purpose program run by an MD PhD expert in lipedema, encompassing Treatment, Research and Education, tissue bank & imaging
  • a genetics project run by a team of lymphedema genetics experts
  • an open-call Fellowship program to improve awareness of lipedema amongst 'young' researchers

In 2016, we

  • commissioned a "disease landscape report" to investigate the existing lipedema research, scout out potential scientific and clinical collaborators, and create a roadmap for future research projects
  • instituted a mouse model project

2017 saw

  • the hiring of our Chief Science Officer
  • our first official grant cycle which resulted in 40 LOIs and 16 awards

Details

2015

$1.5M Treatment, Research and Education of Adipose Tissue (TREAT) Program

Genetic Analysis of Lipoedema

4 Fellowships: 

Mechanisms of Impaired Lymphatic Function in Mice with Increased Adiposity

Functional Imaging of Sodium and Lymphatics in Women with Lipedema

Communication Between Adipose and Lymphatic Microvascular Endothelial Cells

Novel Metabolite-based Treatment Approach of Lymphedema; Possible Relevance for Lipedema?

2016

Understanding Notch Signaling and Lymphatic Dysfunction in Lipedema

2017

Genetic Risk Factors and Corresponding Mechanisms Underlying Lipedema

Molecular and Cellular Characterization of Adipose Stem Cells from Lipedema Patients, and their Role in the Manifestation of Disease in vivo

VEGF-D Induced Lymphangiogenesis; a Novel Approach to Tackle Dysfunctional Adipose Tissue in Lipedema

Identification of Alterations of the Lymphatic and Immune Systems in Lipedema for Use in Diagnosis and Staging

Utilizing Molecular Tissue Profiles and Lymphatic Clearance to Improve Clinical Discriminatory Capacity in Patients with Lipedem 

A Mouse Model of Lipedema, Lower Subcutaneous Adipose Tissue Specific Estrogen Receptor KO

Unraveling Lipedema Pathophysiology

VIPAR - A Novel Potential Diagnostic Approach for 3D Histopathology of Lipedematous Skin Based on Light-sheet Imaging and Automated Data Extraction

An In-depth Analysis of Hyaluronan in the Extracellular Matrix of Adipose Tissue in Lipedema

Investigating the Genetic and Developmental Basis of Lipoedema  

Phenotypic Analysis of Adipose Tissue

Highly Parallel Genome-wide Expression Profiling of Lipedema Tissue on a Single Cell Level using Nanoliter Droplets

Characterization of Lymphatic Function and Adipose Deposition in Early Lipedema

Microenvironmental Cues in Lipedema; Identifying Biomarkers and Exploring Adipose-Macrophage-Lymphatic Endothelium Cross-talk

Activating Calcium Channels to Improve Lymphatic Function in vivo, Using Nanotechnology as a Therapeutic to Ameliorate Local Adipose Deposition