Our Research Grants

In order to define lipedema, we need to better understand what is going on in the affected fat tissue. The image below is a cast of the resident cells and components present in fat tissue. 

Click on a part of the diagram to find out more about its function and the LF grantees actively researching that topic.

Click here to see the Grantees by Institution or By Name and Geography. Scroll down to see Grantees by Project Name.

Our goal is to support research that comprehensively studies the microenvironment in which lipedema forms and persists. Better understanding the status of fat tissue residents and how they interact with one another will shed light on what causes and drives lipedema.

2015

$1.5M Treatment, Research and Education of Adipose Tissue (TREAT) Program

Genetic Analysis of Lipoedema

4 Fellowships: 

Mechanisms of Impaired Lymphatic Function in Mice with Increased Adiposity

Functional Imaging of Sodium and Lymphatics in Women with Lipedema

Communication Between Adipose and Lymphatic Microvascular Endothelial Cells

Novel Metabolite-based Treatment Approach of Lymphedema; Possible Relevance for Lipedema?

2016

Understanding Notch Signaling and Lymphatic Dysfunction in Lipedema

2017

Genetic Risk Factors and Corresponding Mechanisms Underlying Lipedema

Molecular and Cellular Characterization of Adipose Stem Cells from Lipedema Patients, and their Role in the Manifestation of Disease in vivo

VEGF-D Induced Lymphangiogenesis; a Novel Approach to Tackle Dysfunctional Adipose Tissue in Lipedema

Identification of Alterations of the Lymphatic and Immune Systems in Lipedema for Use in Diagnosis and Staging

Utilizing Molecular Tissue Profiles and Lymphatic Clearance to Improve Clinical Discriminatory Capacity in Patients with Lipedem 

A Mouse Model of Lipedema, Lower Subcutaneous Adipose Tissue Specific Estrogen Receptor KO

Unraveling Lipedema Pathophysiology

VIPAR - A Novel Potential Diagnostic Approach for 3D Histopathology of Lipedematous Skin Based on Light-sheet Imaging and Automated Data Extraction

An In-depth Analysis of Hyaluronan in the Extracellular Matrix of Adipose Tissue in Lipedema

Investigating the Genetic and Developmental Basis of Lipoedema  

Phenotypic Analysis of Adipose Tissue

Highly Parallel Genome-wide Expression Profiling of Lipedema Tissue on a Single Cell Level using Nanoliter Droplets

Characterization of Lymphatic Function and Adipose Deposition in Early Lipedema

Microenvironmental Cues in Lipedema; Identifying Biomarkers and Exploring Adipose-Macrophage-Lymphatic Endothelium Cross-talk

Activating Calcium Channels to Improve Lymphatic Function in vivo, Using Nanotechnology as a Therapeutic to Ameliorate Local Adipose Deposition