Enrolling Studies and Clinical Trials

——> Patient Registry <——

25cohort collaboration

INSIGHT at the University of Arizona (info on clinical trial)

Vanderbilt INFORM Survey

Vanderbilt Treatment Study for Lipedema

UTHouston NIRFLI imaging Clinical Trial

Transformative Publications

LF has funded 28 projects over $7m since 2015 and our investments are beginning to yield publications. Click the red links for the summaries of the publications and mechanism to read the publication (may be behind a paywall) or read more on our Research Impact page.

Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue

“Hypertrophic adipocytes, increased numbers of macrophages and blood vessels, and dilation of capillaries in thigh tissue of non-obese women with lipedema suggest inflammation, and angiogenesis occurs independent of obesity and demonstrates a role of altered vasculature in the manifestation of the disease.”

Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

This article describes the impact of the paper: Mobilizing the lymphatic system may help combat obesity-induced metabolic syndrome

Lipedema: Friend and Foe

"In new data collected, lipedema was associated with a low risk of diabetes (2%), dyslipidemia (11.7%) and hypertension (13%) despite an obese average body mass index (BMI) of 35.3 ± 1.7 kg/m2."

Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema.

"CONCLUSIONS: Internal metrics of tissue sodium and adipose content are elevated in patients with lipedema, potentially providing objective imaging-based biomarkers for differentially diagnosing the under-recognized condition of lipedema from obesity."

Adipose stem cells from lipedema and control adipose tissue respond differently to adipogenic stimulation in vitro.

“Lipedema adipose cells not only differ in their lipid storage capacity but also in their adipokine expression pattern.“

Differentiating lipedema and Dercum's disease

"CONCLUSIONS: The significantly lower prevalence of DM2 in people with lipedema compared with DD may be due to the greater amount of gynoid fat known to be protective against metabolic disorders. The high percentage of hypermobility in lipedema patients indicates that it may be a comorbid condition. The location of fat, high average daily pain, presence of lipomas and comorbid painful disorders in DD patients may help differentiate from lipedema."

Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema

Low dose d-amphetamine induced regression of liver fat deposits in Dercum disease

Subcutaneous adipose tissue therapy reduces fat by dual X-ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease

BIOBANK

INSIGHT at The University of Arizona

&gt;10,500 Lipedema Brochures given out. Order yours by clicking on the image.

>10,500 Lipedema Brochures given out. Order yours by clicking on the image.

Defining the lipedema research space

Lipedema is a chronic condition that manifests as a symmetrical buildup of painful fat and swelling in the arms and legs, sparing the hands and feet. It occurs almost exclusively in women and is poorly understood.

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The mission of the Lipedema Foundation is to invest in research that will define, diagnose, and develop treatments for lipedema.