Enrolling Studies and Clinical Trials
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LF has funded 28 projects over $7m since 2015 and our investments are beginning to yield publications. Click the red links for the summaries of the publications and mechanism to read the publication (may be behind a paywall) or read more on our Research Impact page.
“Hypertrophic adipocytes, increased numbers of macrophages and blood vessels, and dilation of capillaries in thigh tissue of non-obese women with lipedema suggest inflammation, and angiogenesis occurs independent of obesity and demonstrates a role of altered vasculature in the manifestation of the disease.”
This article describes the impact of the paper: Mobilizing the lymphatic system may help combat obesity-induced metabolic syndrome
"In new data collected, lipedema was associated with a low risk of diabetes (2%), dyslipidemia (11.7%) and hypertension (13%) despite an obese average body mass index (BMI) of 35.3 ± 1.7 kg/m2."
"CONCLUSIONS: Internal metrics of tissue sodium and adipose content are elevated in patients with lipedema, potentially providing objective imaging-based biomarkers for differentially diagnosing the under-recognized condition of lipedema from obesity."
“Lipedema adipose cells not only differ in their lipid storage capacity but also in their adipokine expression pattern.“
"CONCLUSIONS: The significantly lower prevalence of DM2 in people with lipedema compared with DD may be due to the greater amount of gynoid fat known to be protective against metabolic disorders. The high percentage of hypermobility in lipedema patients indicates that it may be a comorbid condition. The location of fat, high average daily pain, presence of lipomas and comorbid painful disorders in DD patients may help differentiate from lipedema."
Defining the lipedema research space
Lipedema is a chronic condition that manifests as a symmetrical buildup of painful fat and swelling in the arms and legs, sparing the hands and feet. It occurs almost exclusively in women and is poorly understood.
The mission of the Lipedema Foundation is to invest in research that will define, diagnose, and develop treatments for lipedema.