Tim Hucho, Rebecca Dinnendahl, and Philipp Kruppa

Testing applicability of Lipedema-characteristic sensory PPT/VDT measurements in patient-supporting contexts

This research explores the role and real-world applicability of pressure pain and vibration detection thresholds as fast, low-cost, objective, and widely applicable tool for early diagnosis, differential diagnosis, and therapy monitoring in Lipedema, enabling routine clinical use, earlier detection across the lifespan, and rigorous evaluation of established and novel treatments.

Ioanna Yiannakou

The association between Lipedema and cardiometabolic health: Translational epidemiologic research

This project aims to establish the first clinical definition of Lipedema phenotype using a scalable physician-led remote assessment framework in a community-based U.S. cohort and determine its association with cardiometabolic health. Leveraging the Framingham Heart Study, this work will improve Lipedema identification, determine its true prevalence, and cardiometabolic comorbidity.

Karthickeyan Chella Krishnan

Characterizing mitochondrial phenotypes in Lipedema adipose tissue

This research investigates mitochondrial maladaptations in Lipedema adipose tissue by focusing on distinct mitochondrial subpopulations. By comparing Lipedema patients to matched controls, the study aims to identify bioenergetic, structural, and genomic alterations that contribute to disease pathophysiology and provide a foundation for targeted diagnostic and therapeutic strategies.